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Yinbiao Cao

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Sintilimab (PD-1 inhibitor) plus lenvatinib as conversion therapy followed by sequential surgery (SILENSES) for advanced unresectable hepatocellular carcinoma: a phase II, expansion trial

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By Shichun Lu, Wenwen Zhang, Junfeng Li, Ze Zhang, Bingyang Hu, Xuerui Li, Zhijun Wang, Huiyi Ye, Baolin Qu, Yu Li, Guangyu Ma, Tao Wan, Zhe Liu, Bing Liu, Haowen Tang, Xiao Zhao, Liru Pan, Jing Yuan, Ruiqing Chen, Xiangbing Bian, Yinbiao Cao, Zhanbo Wang, Yinzhe Xu
| Nature Verified
Abstract Our previous findings demonstrated the promising antitumor activity and manageable safety of sintilimab-lenvatinib conversion therapy. The current study aimed to evaluate long-term survival outcomes in patients with unresectable hepatocellular carcinoma (HCC) who underwent sequential surgical resection after successful conversion therapy. In this prospective, single-arm, expansion, phase II trial, patients with unresectable HCC received lenvatinib plus sintilimab conversion therapy.
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