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Yinchong Wang on Muck Rack

Yinchong Wang

As seen in: The BMJ, The Journal of Clinical Investigation
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Articles

Therapy-induced senescence rewires the melanoma secretome to promote antitumor immune response and augment cell therapies

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By Marina Capece, Yinchong Wang, Evdokiya Reshetnikova
| The BMJ Verified
Many pharmacological agents used in oncology can induce senescence in malignant cells. Therapy-induced senescence (TIS) is associated with a secretory program that includes various immune mediators and can vary extensively based on the drug and tumor type. The impact of TIS on the tumor immune microenvironment must be studied to harness senescence as a tool to enhance antitumor immunity and immunotherapy responses in cancer.
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TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING

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By JCI Insight, Vijaya Bharti, Amrendra Kumar, Yinchong Wang
| The Journal of Clinical Investigation
ResearchOncology Open Access | 10.1172/jci.insight.177523 JCI Insight. https://doi.org/10.1172/jci.insight.177523. Copyright © 2024, Bharti et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract TTK (MPS1) spindle assembly checkpoint kinase is an emerging cancer target.
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