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Yinda Yu on Muck Rack

Yinda Yu

As seen in: Nature
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Articles

Integrative single-cell analysis reveals endothelial diversity in the vasa vasorum of human atherosclerosis

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By Yanzhao Wu, Zhiwei Xue, Tao Lin Sun, Wenchen Xing, Feiyu Mu, Zhihan Zhang, Meilin Lv, Lu Ling, Mengtao Han, Lian Cheng, Anton Gisterå, Donghai Wang, Yinda Yu, Xiangjun Liang
| Nature Verified
Abstract Microvessels within atherosclerotic plaques are crucially involved in disease progression. Here, we generated a transcriptomic atlas of human atherosclerosis at single-cell resolution, encompassing 17,367 vascular endothelial cells (VECs) from five scRNA-seq studies, and verified key morphological characteristics using histology. SULF1+ arterial endothelial cells (ArtECs) represented the primary subcluster undergoing endothelial-to-mesenchymal transition (EndMT).
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