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Yinfang Wang on Muck Rack

Yinfang Wang

As seen in: Nature
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Articles

Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease

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By Peiran Yin, Lumiao Chen, Mengyang Ding, Mengjun Xie, Hu Zhang, Yuan Qin, Haozhe Ding, Ying Lu, Xun Zhou, Qiansen Zhang, Pan Fang, Kai Song, Qifei Cong, Zhaonan Wei, Anran Huo, Yinfang Wang
| Nature Verified
Abstract Disrupted iron homeostasis is a critical pathological feature of chronic kidney disease (CKD) and drives renal fibrosis and disease progression, but the underlying regulatory mechanisms linking iron dysregulation to renal fibrosis remain poorly defined. Here, we identify sushi repeat-containing protein X-linked 2 (SRPX2) as a novel pathogenic regulator of renal fibrosis that dysregulates tubular cellular iron metabolism.
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