Peiran Yin

Abstract Disrupted iron homeostasis is a critical pathological feature of chronic kidney disease (CKD) and drives renal fibrosis and disease progression, but the underlying regulatory mechanisms linking iron dysregulation to renal fibrosis remain poorly defined. Here, we identify sushi repeat-containing protein X-linked 2 (SRPX2) as a novel pathogenic regulator of renal fibrosis that dysregulates tubular cellular iron metabolism.

Abstract A central goal in neuroscience is to clarify how neural circuits translate sensory input into adaptive behaviours. Although unisensory evoked escape circuits in mice are well defined, it remains unclear whether a single nucleus contains specialized sensory, sensory‒motor decision, and motor command neurons for escapes driven by distinct sensory cues, and how these neurons form functional microcircuits.

Abstract Dark energy, a mysterious form of energy that pervades the entire Universe, is believed to be responsible for the Universe’s accelerated expansion. Various theoretical attempts have been made to explain the elusive nature of dark energy. One of the compelling theories is the so-called symmetron dark energy, which predicts a fifth force that interacts with matter. However, the screening of the fifth force in high-density environments poses a challenge for laboratory experiments.