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A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation
Highlights • DGCR8 binds to nascent mRNAs, inhibiting their transcription by sequestering FLII • Phosphorylated FLII, induced by the ERK pathway, dissociates from DGCR8 and binds to JUN • FLII facilitates JUN in activating gene expression related to cell migration • The interplay a DGCR8/FLII/JUN governs morphogenesis of implanting embryos Summary During implantation, embryos undergo an unpolarized-to-polarized transition to initiate postimplantation morphogenesis.
Advancing theory development: exploring the leadership-climate relationship as a mechanism of the implementation of cultural competence
Health care organizations require leadership to implement practices that are effective and culturally responsive to the increasing racial and ethnic diversity of the US population. To address the well-established disparities between health outcomes of racial and ethnic minorities compared to Whites, federal and private institutions have supported the implementation of culturally competent practices [1, 2].
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