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Polygonati Rhizoma Attenuates Oxidative Stress-Induced Senescence in Periodontal Ligament Stem Cells
1 Introduction Periodontitis is the primary cause of tooth loss in adults and is characterized by chronic infection that results in the progressive loss of epithelial attachment and alveolar bone (Papapanou et al. 2018). The global prevalence of periodontitis is estimated between 20% and 50% (Czesnikiewicz-Guzik et al. 2019).
Editorial: The immune microenvironment-microbiome interactions in peri-implantitis and periodontitis
Introduction Peri-implantitis and periodontitis are highly prevalent chronic inflammatory diseases and leading causes of tooth and implant loss worldwide (; ). They do not result solely from pathogenic microorganisms but from a dysregulated host response to a dysbiotic microbiota (; ). The interplay between microbial communities and the local immune microenvironment governs disease progression.
Role of lactylation modification in regulating lytic cell death
1 Introduction Lactate, traditionally considered a metabolic byproduct of glycolysis under hypoxic conditions, is increasingly recognized as a crucial energy carrier and a signaling molecule involved in intracellular signal transduction (1). Moreover, lactate influences regulatory processes at both transcriptional and protein functional levels (2–4). In 2019, Zhao et al.
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