Ying Ann Chiao
United States
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Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases
Highlights NAD+ is a coenzyme regulating cellular and mitochondrial metabolic processes and signaling. Reduced NAD+ levels and NAD+/NADH ratio have been observed in experimental models of cardiometabolic diseases and associated with mitochondrial dysfunction. Recent evidence highlights the potential of targeting NAD+ redox, synthesis and consumption, and compartmentalization to develop intervention strategies for cardiometabolic diseases.
Semaglutide in Heart Failure With Preserved Ejection Fraction: Benefits Above and Beyond Weight Loss∗
Introduction Heart failure with preserved ejection fraction (HFpEF) is becoming the most common type of heart failure (HF) and unfortunately has very limited therapeutic options. HFpEF is a complex condition influenced by various risk factors such as aging, hypertension, obesity, and diabetes mellitus. Approximately 80% of individuals diagnosed with HFpEF are overweight or obese.
Mitochondrial oxidative stress in aging and healthspan
Dao-Fu Dai†1, Ying Ann Chiao†1, David J Marcinek2, Hazel H Szeto3 and Peter S Rabinovitch1Email author Longevity & Healthspan20143:6 https://doi.org/10.1186/2046-2395-3-6 © Dai et al.; licensee BioMed Central Ltd.
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