Ying-Bo Shao

Abstract Chiral helicenes and their derivatives are valuable across diverse research fields, yet the development of helical chirality has lagged far behind that of point and axial chirality. The synthesis of polychiral or heteroatom-containing helical systems remains especially challenging because of limited starting materials and difficulties in stereochemical control.

Abstract Click to copy section linkSection link copied! Enantioenriched β-allyl carbonyl compounds constitute an important class of versatile chiral building blocks that can be transformed into a variety of intermediates and utilized in the synthesis of numerous biologically active natural products. Catalytic enantioselective conjugate allyl addition to simple α,β-unsaturated esters provides one of the most efficient approaches for access to such moieties.