Ying Cheng
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Ghrelin Alleviates Aging-Related Cognitive Impairment by Regulating Autophagy-Related Signaling via the SHBG/JNK1/Beclin1 Axis in Microglia
1 Introduction Cognitive impairment (CI) is a prevalent, age-related condition characterized by progressive deficits in memory, attention, and executive functions that impair activities of daily living (Gordon and Martin 2013; Tangalos and Petersen 2018). CI is clinically stratified from mild cognitive impairment (MCI), which represents an intermediate state between normal aging and dementia, to more severe forms associated with Alzheimer's disease and vascular dementia (Gordon and Martin 2013).
Espanyol: gramàtica básica
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Disitamab vedotin for HER2-positive breast cancer with liver metastases: phase 3 results from the RC48-C006 phase 2/3 trial
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Abstract Patients with HER2-positive advanced breast cancer with liver metastases (BCLM) have poor prognosis. Study RC48-C006 is a prospective, open-label, multi-center, randomized phase 2/3 trial (ClinicalTrials.gov identifier, NCT03500380). Based on the phase 2 results, the phase 3 stage was initiated to evaluate disitamab vedotin (DV) versus lapatinib plus capecitabine (L + C) in patients with HER2-positive BCLM who were previously treated with trastuzumab and taxanes.
By Jiayu Wang, Quchang Ouyang, Weimin Xie, Zhaofeng Niu, Qingyuan Zhang, Jianying Chang, Ying Cheng, Airong Wang, Jingfen Wang, Herui Yao, Tao Lin Sun, Zhongsheng Tong, Xinhong Wu, Yongsheng Wang, Enxiang Zhou, Xiangshun Kong, De Zeng, Shanshan Gu, Yanyan Hou, Dandan Gao, Jianmin Fang, Binghe Xu, Yue’e Teng, Zhuangqing Yang, Xujuan Wang, Zerui Qu, Chenran Han
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Nature
Verified
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