Ying-Chih Liao
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Evaluating CAR-T cells from neurofibromatosis type 1 (NF1) patients for targeting AXL in malignant peripheral nerve sheath tumors associated with NF1 - British Journal of Cancer
Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by neurofibromas, with 5–13% of patients risk developing malignant peripheral nerve sheath tumors (MPNST). Current treatments for MPNST are largely ineffective. AXL, overexpressed in MPNST, is a potential target for Chimeric Antigen Receptor T (CAR-T) cell therapy. This study evaluates the immunophenotypes, efficacy, and safety of NF1-derived AXL-CAR-T cells in treating MPNST.
Cognitive decline after ventriculoperitoneal shunt surgery for normal pressure hydrocephalus
Dear Editor, Normal pressure hydrocephalus (NPH) is caused by excess cerebrospinal fluid (CSF) in the brain ventricles. The classic triad of NPH includes gait disturbance, urinary incontinence, and cognitive dysfunction. Inserting a ventriculoperitoneal shunt (VPS), to drain excess CSF from the brain to the abdomen, is the first-line treatment for individuals with NPH.
FT895 Impairs Mitochondrial Function in Malignant Peripheral Nerve Sheath Tumor Cells
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