Ying Deng
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Molecular epidemiology and antimicrobial resistance of human Streptococcus suis isolates in Guangxi, China, 2015–2021
Abstract Background: Streptococcus suis (S. suis) is an important zoonotic pathogen and a common colonizer of the upper respiratory tract of pigs. Human infections have been reported in several regions of China, including Guangxi, but genomic and antimicrobial resistance data from this region remain limited. This study investigated the molecular epidemiology, antimicrobial susceptibility, and genomic characteristics of human S. suis isolates collected in Baise City, Guangxi, from 2015 to 2021.
Multi-omics Mendelian randomization and experimental validation suggest MAPK3 as a potential drug target for knee osteoarthritis
Abstract Knee osteoarthritis (KOA) is a major cause of pain and disability, yet effective disease-modifying treatments remain limited. Endoplasmic reticulum stress contributes to joint degeneration, but genetically supported targets remain unclear. We integrated blood eQTL, plasma pQTL, and KOA GWAS data using Mendelian randomization and colocalization analyses.
Psychosocial distress and associated factors among pneumoconiosis patients: a cross-sectional study
Abstract Background and aims: Pneumoconiosis is a chronic pulmonary disease characterized by diminished physical function, impaired mental health, and deteriorated socioeconomic status. The study aims to evaluate the status of psychosocial distress and identify its associated factors in patients with pneumoconiosis.
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