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Development and validation of a nomogram for early prognostic prediction in childhood aplastic anemia receiving cyclosporine monotherapy
Abstract The prognosis for aplastic anemia (AA) patients undergoing cyclosporine is variable; therefore, a prognostic model is needed to optimize stratified treatment strategies. This observational retrospective cohort study included patients with AA who received immunosuppressive therapy with cyclosporine. A total of 437 patients were randomly assigned to the training cohort (n = 262) or the validation cohort (n = 175) at a ratio of 6:4.
High proportion of peripheral blood and haploidentical stem cell transplantation in Chinese children: a nationwide CCBMTR analysis
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To Editor, Dedicated China pediatric HCT centers in China began performing hematopoietic cell transplantations (HCTs) in 1998, following sporadic early cases. Over the past 28 years, pediatric HCT has expanded from a nascent service to a large-scale national practice.
By Chengjuan Luo, Ruijuan Sun, Uet Yu, Sixi Liu, Xiaodong Wang, Shaoyan Hu, Chunfu Li, Maoquan Qin, Yuan Sun, Hua Jiang, Dao Wang, Xiaoqin Feng, Ying Dou, Yiping Zhu, Rong Liu, Yifei Cheng, Xiaowen Zhai, Hongmei Wang, Xiaofan Zhu, Ke Huang, Xiangfeng Tang, Zhi Chen, Yanna Mao, Yunyan He, Kai Chen, Yongjun Fang, Xiaojun Xu, Li Wang, Xiaoyan Wu, Ning Xue, Libin Huang, Caili Wang, Xiangmei Zhang, Xiaojun Yuan, Rong Zhang, Rui Yang, Xin Tian, Aiguo Liu, Xiujuan Dong, Jie Cheng, Chuan Wen, Chun C Chen, Xianjing Wang, Ningling Wang, Yanxia Zhao, Ying Fu, Xiaodong Shi, Jing Huang, Hongyu Shi, Haixia Cao, JING CHEN, Benshan Zhang, Futian Ma, Liangchun Yang, Huihe Tang
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Nature
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Molecular classification and outcomes in pediatric aplastic anemia with myeloid neoplasm-associated gene variants
Department of Hematology and Oncology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China Background: The genetic variations in aplastic anemia (AA) patients are closely related to clonal hematopoiesis, but there is limited research on this topic in children with AA.
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