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Structural and kinetic mechanisms of state-dependent potassium channel inhibition
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The KCNQ1 (Kv7.1) potassium ion (K+) channel plays a critical role in cardiac repolarization, while loss- or gain-of-function mutations increase the risk of life-threatening arrythmias and sudden death.
Development and validation of a nomogram for early prognostic prediction in childhood aplastic anemia receiving cyclosporine monotherapy
Abstract The prognosis for aplastic anemia (AA) patients undergoing cyclosporine is variable; therefore, a prognostic model is needed to optimize stratified treatment strategies. This observational retrospective cohort study included patients with AA who received immunosuppressive therapy with cyclosporine. A total of 437 patients were randomly assigned to the training cohort (n = 262) or the validation cohort (n = 175) at a ratio of 6:4.
High proportion of peripheral blood and haploidentical stem cell transplantation in Chinese children: a nationwide CCBMTR analysis
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To Editor, Dedicated China pediatric HCT centers in China began performing hematopoietic cell transplantations (HCTs) in 1998, following sporadic early cases. Over the past 28 years, pediatric HCT has expanded from a nascent service to a large-scale national practice.
By Chengjuan Luo, Ruijuan Sun, Uet Yu, Sixi Liu, Xiaodong Wang, Shaoyan Hu, Chunfu Li, Maoquan Qin, Yuan Sun, Hua Jiang, Dao Wang, Xiaoqin Feng, Ying Dou, Yiping Zhu, Rong Liu, Yifei Cheng, Xiaowen Zhai, Hongmei Wang, Xiaofan Zhu, Ke Huang, Xiangfeng Tang, Zhi Chen, Yanna Mao, Yunyan He, Kai Chen, Yongjun Fang, Xiaojun Xu, Li Wang, Xiaoyan Wu, Ning Xue, Libin Huang, Caili Wang, Xiangmei Zhang, Xiaojun Yuan, Rong Zhang, Rui Yang, Xin Tian, Aiguo Liu, Xiujuan Dong, Jie Cheng, Chuan Wen, Chun C Chen, Xianjing Wang, Ningling Wang, Yanxia Zhao, Ying Fu, Xiaodong Shi, Jing Huang, Hongyu Shi, Haixia Cao, JING CHEN, Benshan Zhang, Futian Ma, Liangchun Yang, Huihe Tang
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Nature
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