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Spliceosome buffers cryptic genetic variation to enforce phenotypic robustness in Arabidopsis
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cryptic genetic variations (CGVs), which are phenotypically silent under normal conditions, can compromise phenotypic robustness when unmasked. Canalization buffers CGV to stabilize phenotypes, yet the underlying molecular mechanisms remain largely unknown.
Long-term outcomes of adjuvant metronomic capecitabine in locoregionally advanced nasopharyngeal carcinoma: a randomized, controlled, multicenter, phase 3 study
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Abstract Here we report long-term outcomes of adjuvant metronomic capecitabine in patients with locoregionally advanced nasopharyngeal carcinoma. In this multicenter, open-label, parallel-group, randomized, controlled, phase 3 trial, 406 patients who had completed definitive chemoradiotherapy were randomly assigned (1:1) to receive either adjuvant metronomic capecitabine (650 mg m−2 twice daily for 1 year) or observation.
By Ya-Lan Tao, Dong-Hong Wu, Qin Zhou, Kun-Yu Yang, Feng Jin, Xiao-Dong Zhu, Mei Shi, Guo-Qing Hu, Yan Sun, Hong-fen Wu, Hui Wu, Qin Lin, Hui Wang, Ye Tian, Ning Zhang, Xi-Cheng Wang, Liang-Fang Shen, Zheng-zheng Liu, Jing Huang, Jian Zang, Bao-Min Zheng, Dan Yue, Jing Xu, San-Gang Wu, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Rui Sun, Rui Guo, YUAN ZHANG, Cheng Xu, Jia-Wei Lv, Ying Guo, Ling-Long Tang, Fang-Yun Xie, Xu Liu, Ying Sun, Jun Ma, Yan-Ping Mao, Yu-Pei Chen, Xiu-Ling Luo, Hui-Xia Feng
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Nature
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Enabling Synergistic Adsorption–Catalysis in Li–S Batteries by MOF-Derived Cobalt-Doped Porous Carbon Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Lithium–sulfur (Li–S) batteries offer high theoretical energy density but suffer from sluggish polysulfide conversion kinetics and the severe shuttle effect, leading to rapid capacity decay and poor rate performance. Herein, a cobalt-doped hierarchically porous carbon (Co-HPC) is rationally designed via pyrolysis of Co-doped Zn-BTC metal–organic frameworks (MOFs) to enable synergistic polysulfide adsorption and catalytic conversion.
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