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Ying-Han Chen on Muck Rack

Ying-Han Chen

As seen in: Color Research & Application, Nature, PLOS, PLOS Biology, Science Magazine, Royal Society of Chemistry, Cell Press
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Articles

DFT calculations guide the design of dual-responsive molecule 9,10-phenanthrenequinone-sydnone

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By Cheng Tang, Wenyuan Xu, Ying-Han Chen, Hongzhe Yu
| Royal Society of Chemistry Verified
DFT calculations guide the design of dual-responsive molecule 9,10-phenanthrenequinone-sydnone With the aid of density functional theory (DFT) calculations, we designed and synthesized a dual-responsive molecule 9,10-phenanthrenequinone-sydnone PQ-Syd, enabling tandem orthogonal reactions with furan-2(3H)-one derivatives and bicyclo[6.1.0]nonyne (BCN) for turn-on and fluorescence modulation. The PQ-Syd has been applied for the protein labeling, and has potential for rapid screening of cells.
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Rewilding catalyzes maturation of the humoral immune system

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By Bethan Linscott, Fabian Fischer, Ying-Han Chen, Kimberly Zaldana
| Science Magazine Verified
Abstract Inbred mice used for biomedical research display an underdeveloped immune system compared with adult humans, which is attributed in part to the artificial laboratory environment. Despite representing a central component of adaptive immunity, the impact of the laboratory environment on the B cell compartment has not been investigated in detail.
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Genetic and environmental interactions contribute to immune variation in rewilded mice - Nature Immunology

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By Oyebola Oyesola, Alexander E Downie, Nina Howard, Ramya S. Barre, Ying-Han Chen, Arthur R. Menezes, soo lee, Ken Cadwell, Andrea Graham
| Nature Verified
Abstract The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite implications in evolutionary biology and medicine. Here we quantify interactive effects of genotype and environment on immune traits by investigating C57BL/6, 129S1 and PWK/PhJ inbred mice, rewilded in an outdoor enclosure and infected with the parasite Trichuris muris.
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