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Ying-Hsi Lin on Muck Rack

Ying-Hsi Lin

As seen in: BioRxiv, Stem Cell Reports, Biochemistry & Cell Biology
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Articles

Cardiac Adaptations in the Cave Nectar Bat Eonycteris spelaea: Insights into Metabolic Resilience and Stress Response

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By Fan Yu, Akshamal M. Gamage, Randy Foo, Ying-Hsi Lin
| BioRxiv
Funder Information Declared Singapore Ministry of Health’s National Medical Research Council Singapore, MOH-STaR21jun-0003, NMRC CG21APR1006 National Research Foundation Competitive Research Program, NRF CRP25-2020RS-0001 RIE2020/RIE2025 PREVENT-HF Industry Alignment Fund Pre-Positioning Programme, IAF-PP H23J2a0033 CArdiovascular DiseasE National Collaborative Enterprise (CADENCE) National Clinical Translational Program, MOH-001277-01 Academic Medicine-Designated Philanthropic Fund,...
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HDAC6 modulates myofibril stiffness and diastolic function of the heart

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By Ying-Hsi Lin, Jennifer L. Major, Zaynab Hourani, Tim Liebner
| The Journal of Clinical Investigation
Abstract Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. We found that myofibril stiffness was elevated in mice lacking histone deacetylase 6 (HDAC6).
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Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy

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By Walter E. Knight, Yingqiong Cao, Ying-Hsi Lin, Congwu Chi
| Stem Cell Reports Verified
Highlights • Standard (glucose) cultured hiPSC-CMs demonstrate a blunted hypertrophic response • A maturation method induces hiPSC-CM maturation and suppresses HIF1A expression • Mature hiPSC-CMs demonstrate improved sarcomeric morphology and contractility • Mature hiPSC-CMs respond to agonist- or mutation-induced hypertrophy Summary Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research.
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