Ying-Jan Wang

Abstract Zinc oxide nanoparticles (ZnONPs) are widely used in sunscreens and cosmetics; however, increasing evidence suggests their potential to induce skin toxicity, particularly under conditions of skin function disruption. Here, we investigated the mechanisms underlying allergic skin inflammation triggered by repeated ZnONPs exposure following UVR damage using an in vivo hairless mouse model and in vitro Adverse Outcome Pathway (AOP)-based new approach methodologies (NAMs).

1 Introduction Metastasis—the spread of cancer cells beyond the primary tumor to remote organs—is a complex, multi-step process and the leading cause of cancer mortality, accounting for over 90% of cancer-associated deaths [1].

Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene Engineered nanoparticles raise safety concerns. Silver nanoparticles (AgNPs) exert acute and chronic adverse effects by inducing reactive oxygen species (ROS)-mediated stress signaling pathways. We investigated the mechanisms by which AgNPs exert lasting adverse effects on longevity, as well as their sublethal effects on functional aging.