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Yu-Ying Chen on Muck Rack

Yu-Ying Chen

As seen in: Nature, MDPI, Science Magazine, Royal Society of Chemistry, BioRxiv, eLife, The Journal of Biological Chemistry
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Articles

Using new approach methodologies (NAMs) to investigate ZnONPs and UVR induced skin sensitization

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By Yu-Ying Chen, Yung-Hsuan Cheng, Ying-Jan Wang, Hsien-Jen Cheng
| Nature Verified
Abstract Zinc oxide nanoparticles (ZnONPs) are widely used in sunscreens and cosmetics; however, increasing evidence suggests their potential to induce skin toxicity, particularly under conditions of skin function disruption. Here, we investigated the mechanisms underlying allergic skin inflammation triggered by repeated ZnONPs exposure following UVR damage using an in vivo hairless mouse model and in vitro Adverse Outcome Pathway (AOP)-based new approach methodologies (NAMs).
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Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation

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By Adi Rotem, Sixian Qi, Aristeidis G Telonis, Yu-Ying Chen
| Science Magazine Verified
Abstract Sex determination of mammalian gonads hinges upon sex-specific differentiation of gonadal supporting cells: Sertoli cells in the testis and granulosa cells in the ovary. To gain insights into how supporting cells acquire their identities, we performed joint single-nucleus transcriptomics and chromatin accessibility assays on murine gonadal cells during sex determination.
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Transcriptomic analysis of whole staged ovarian follicles reveals stage-specific folliculogenesis signatures in mice

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By Hannah VanBenschoten, Yu-Ying Chen, Olha Kholod
| BioRxiv
Abstract Activation and maturation of ovarian follicles are essential for female reproduction, yet the underlying molecular and transcriptional mechanisms that govern these processes remain poorly understood. In this study, we used single follicle RNA-sequencing (RNA-seq) to identify transcriptional signatures of staged ovarian follicles, from primordial to secondary stages, to uncover the genes and pathways involved in early folliculogenesis.
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