Ying Kong
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CACUL1 promotes hepatocellular carcinoma progression through enhanced tumor cell proliferation and macrophage-mediated immune suppression
Abstract Background: Although cullin-family E3 ubiquitin ligases regulate diverse oncogenic pathways, the role of CACUL1 in hepatocellular carcinoma (HCC) remains poorly characterized. Methods: We performed pan-cancer expression and survival analysis using TCGA and GEO databases, validated findings through immunohistochemistry, and conducted functional studies in HCC cell lines using CRISPR-mediated CACUL1 knockout.
Understanding hypoparathyroidism as a disease of broad functional deficiency
ReviewOnline nowOpen access Affiliations & Notes 1FIRMO Italian Foundation for the Research on Bone Diseases, Florence, Italy 2Thyroid-Endocrine Tumors Department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France 3Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary 4Global Medical Affairs, Alexion, AstraZeneca Rare Disease, Boston, MA, USA 5Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark 6Division of...
Predictive Screening of Ta 4 C 3 MXene as an Inhalable Nanotherapeutic Based on an Advanced 3D Air–Liquid Interface Lung Model Click to copy article link Article link copied!
Pulmonary diseases, such as acute lung injury and fibrosis, represent a significant global health burden, necessitating innovative therapeutic strategies that can directly target the affected tissue with minimal systemic exposure. Inhalation-based drug administration offers a noninvasive approach for treating pulmonary diseases by delivering therapeutics directly to the lungs while reducing systemic side effects.
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