Ying Luan

Keywords caspase-4 gasdermin D cryo-EM stepwise maturation interdomain linker Get full text access Log in, subscribe or purchase for full access. References 1. Shi, J. ∙ Zhao, Y. ∙ Wang, Y. ... Inflammatory caspases are innate immune receptors for intracellular LPS Nature. 2014; 514:187-192 2. Thornberry, N.A. ∙ Bull, H.G. ∙ Calaycay, J.R. ... A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes Nature. 1992; 356:768-774 3. Devant, P. ∙ Dong, Y. ∙ Mintseris, J. ...

Abstract Synaptic loss strongly correlates with cognitive impairment in Alzheimer’s disease (AD), yet the mechanism linking its origin and pattern remain unclear. Given that connected brain regions share molecular and synaptic features, and pathological tau, a key driver of synaptic degeneration, propagates through brain networks, we hypothesize that network architecture may influence synaptic loss in AD.

1. Introduction Air pollution has emerged as a pressing environmental concern globally, with air quality emerging as a crucial environmental concern of current focus []. In particular, fine particulate matter (PM2.5) and ozone (O3) have been substantiated as major air pollutants that exert severe adverse impacts on human health and agricultural productivity []. Research has shown that these air pollutants can induce respiratory diseases, cardiovascular diseases, and other chronic conditions [].