Ying Meng
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Statistics > Machine Learning
Automated materials discovery requires evaluating large pools of candidate configurations, with density functional theory (DFT) as a major throughput bottleneck. Pretrained machine-learned interatomic potentials (MLIPs) approximate DFT cheaply, but their errors vary by orders of magnitude across configurations, making it difficult to decide when to trust the MLIP predictions and when to fall back to DFT.
p38 MAP kinase senses short-chain fatty acids to attenuate Toll-like receptor signaling and intestinal inflammation
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgment Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Toll-like receptor (TLR) signaling is critical for innate immune system. However, whether it is directly modulated by microbiota-derived metabolites remains unclear.
Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion
Keywords lactate STING PKM2 LDHA EGFRvIII PD-1 immune evasion Get full text access Log in, subscribe or purchase for full access. References 1. Li, T. ∙ Chen, Z.J. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer J. Exp. Med. 2018; 215:1287-1299 2. Roers, A. ∙ Hiller, B. ∙ Hornung, V. Recognition of Endogenous Nucleic Acids by the Innate Immune System Immunity. 2016; 44:739-754 3. Sun, L. ∙ Wu, J. ∙ Du, F. ...
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