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Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding
Highlights • Rostromedial tegmental (RMTg) neurons are activated by punishment-related stimuli • Distinct RMTg afferents communicate distinct punishment-related signals • These RMTg afferents drive correspondingly distinct aspects of punishment learning • Negative valence encoding in the ventral tegmental area depends on the RMTg Summary Persistence of reward seeking despite punishment or other negative consequences is a defining feature of mania and addiction, and numerous brain regions have...
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