Ying Sui
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Multimodal MRI Reveals Stage-Specific Reorganization of Structure-Function Coupling from Compensatory to Decoupled States in Cerebral Small Vessel Disease
Key Words Brain network Cerebral small vessel disease Functional connectivity Structural connectivity Structural–functional coupling INTRODUTION Cerebral Small Vessel Disease (CSVD) ranks among the leading causes of vascular cognitive impairment and dementia. Its pathological changes mainly involve the perforating arterioles, capillaries and small veins of the brain (1,2).
Structural changes in gray matter and white matter across the Alzheimer’s disease continuum
Abstract Objective: The pathophysiological spectrum of Alzheimer’s disease (AD) is a continuum, with the AT(N) framework defining stages based on the presence of Aβ pathology, tau pathology, and neurodegeneration. However, the spatial characteristics of gray matter (GM) and white matter (WM) changes at different stages remain insufficiently defined.
Suppressing the OTUD7A/KDM5B/GABPA axis enhances the sensitivity of cisplatin through inducing ferroptosis in KRAS-mutant LUAD - Cell Death & Disease
Abstract KRAS-mutant lung adenocarcinoma (LUAD), due to its evolution of more complex antioxidant metabolic mechanisms, exhibits poorer sensitivity to conventional platinum-based drugs compared to other types of LUAD. Ferroptosis, as a means of inducing cell death in cancer therapy, shows unique features and potential therapeutic effects compared to the conventional form of apoptosis, which is frequently obstructed by drug resistance.
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