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Ying Swan Ho

As seen in: Nature, Wiley Online Library, Cell Metabolism
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Articles

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D

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By Ashar Malik, Dimitar Kenanov, Cheng-Shoong Chong, Mert Öztürk, Qiqi Wang, Maxime Hebrard, Ying Swan Ho, Zhenxun Wang, Srinivasaraghavan Kannan, Roberto Magallanes, Xueling Sim, Jin Chai, Sonia Davila, Khung Keong Yeo, Khai Pang Leong, Liuh Ling Goh, Neerja Karnani, Johan Eriksson, Ching-Yu Cheng, Marie Loh, Rinkoo Dalan, Chiea Chuen Khor, Guo-Liang Chew, Weng Khong Lim, Joanne Ngeow, John Chambers, E. Shyong Tai, Nicolas Bertin, Patrick Tan, Chandra Verma, Sebastian Maurer-Stroh, Hong-Yun Chang, Vachiranee Limviphuvadh, Jhoann M. T. Miyajima, Judice Koh
| Nature Verified
Abstract One of the promises of precision medicine is to understand and act on inter-individual genetic differences in drug responses. SNPdrug3D contains the complete genomic landscape of missense single nucleotide variants (SNV) across the human proteome and at a population-wide level that could affect drug binding.
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Rational design of serum-free media for cultivated meat

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By Yin Ho, Ying Swan Ho, Meiyappan Lakshmanan, Sanjay Sivakumar
| Nature Verified
The commercialization of cultivated meat remains limited by the high cost of cell culture medium. Here, we discuss how multi-omics characterization and computational modelling can enable the design of cell line-specific, serum-free medium using valorized sources, offering improved cost-efficiency and sustainability.
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Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer

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By Zhengwei Wu, Zhenxun Wang, Seow Qi Ng, Jessica Alice Lidster, Paul Schwerd-Kleine, Yin Ho, Ju Yuan, S. Shathishwaran, Xun Hui Yeo, Ying Zhang, Angela M. Takano, Eng Huat Tan, Anders Jacobsen Skanderup, Vinay Tergaonkar, Weiping Han, Ying Swan Ho, Wai Leong Tam
| Cell Metabolism Verified
Keywords metabolic reprogramming ketone metabolism ketogenic diet tumor-initiating cells MCT1 monocarboxylate transporter CD147 glucose stress lung cancer Introduction Metabolic reprogramming is a hallmark of cancer,1 enabling tumor cells to meet increased biosynthetic and energetic demands.
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