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Ying Ting Sit on Muck Rack

Ying Ting Sit

As seen in: Stem Cell Reports, The Journal of Clinical Investigation
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Articles

Single-cell transcriptomics reveal individual and cooperative effects of trisomy 21 and GATA1s on hematopoiesis

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By Kaoru Takasaki, Eric Wafula, Jian Fan, Ying Ting Sit, Sara Kumar, David SMith, David Smith, Alyssa Gagne, Deborah French, Christopher S Thom, Stella T Chou, Peter A. Gearhart
| Stem Cell Reports Verified
Introduction Trisomy 21 (T21), or Down syndrome (DS), is associated with erythrocytosis, thrombocytopenia, and neutrophilia (Miller and Cosgriff, 1983; Henry et al., 2007), as well as two clonal disorders of hematopoiesis: transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS) (McNulty and Crispino, 2020; Roberts et al., 2013).
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Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis

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By JCI Insight, Ying Ting Sit, Kaoru Takasaki, Hyun Hyung An
| The Journal of Clinical Investigation
ResearchHematology Open Access | 10.1172/jci.insight.172851 JCI Insight. https://doi.org/10.1172/jci.insight.172851. Copyright © 2023, Sit et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Patients with Down syndrome (DS, trisomy 21, T21) are at increased risk of transient abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS).
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