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Articles by Ying Wang
Author Correction: Serine protease inhibitor A3 is a soluble SIRPα ligand that suppresses inflammation and antitumor immunity
Correction to: Nature Immunology https://doi.org/10.1038/s41590-026-02682-5, published online 22 October 2026. In the version of this article initially published, due to figure file-preparation mistakes, there were errors in Figs. 1–6. In Fig. 1i, incorrect blot images were presented; in Fig. 2j, an x-axis label and arrow were missing; in Fig. 3d, e, incorrect flow cytometry plots were shown, while a bar plot in Fig. 3e and a header label in Fig. 3f were omitted; in Figs.
Hereditary hemorrhagic telangiectasia type 1 with an ENG nonsense mutation presenting with severe pulmonary hypertension and recurrent pulmonary arteriovenous malformations in a nonagenarian: a case report
Abstract Background: Hereditary hemorrhagic telangiectasia type 1 (HHT1) is caused by mutations in the ENG gene, with functional deficiency of endoglin serving as the core pathogenic mechanism leading to multiple arteriovenous malformations. Nonsense mutations in ENG typically result in a truncated protein and induce haploinsufficiency, representing a key pathogenic mechanism underlying HHT1.
A review of the application and development of inflatable structures in functional clothing
Abstract This study provides a comprehensive overview of the research and application of inflatable structures in functional clothing, emphasizing their potential for dynamic adaptability, intelligent responsiveness, and multifunctional integration. It begins by examining the classification and working principles of inflatable structures, followed by a review of their diverse applications in sports protection, medical rehabilitation, and other additional functions.
Transforming Pathological H 2 S Into a Photodynamic Amplifier: In Vivo Formation of Bi 2 O 2 CO 3 @Bi 2 S 3 Heterojunction for Microenvironment-Adaptive Periodontitis Treatment
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adma75577-sup-0001-SuppMat.docx6.3 MB Supporting File: adma75577-sup-0001-SuppMat.docx.
Artificial intelligence in radiology education: from AI-supported learning to clinical innovation—a narrative review
Abstract Artificial intelligence (AI) is changing diagnostic radiology, but education and training have not kept pace. This narrative review brings together current evidence on AI-supported learning in radiology education and how such learning can move into clinical innovation.
Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS)
Abstract The integration of anthracyclines with HER2-targeted agents in neoadjuvant therapy for HER2-positive breast cancer has been limited by cardiotoxicity concerns. This randomized phase II METIS trial (NCT04172259) assessed whether concurrent pegylated liposomal doxorubicin (PLD)-containing chemotherapy plus dual HER2 blockade (trastuzumab/pertuzumab) could improve efficacy without increasing cardiac risk.
Dual targeting of ACSS2 and ACLY by a novel inhibitor S8588 suppresses oncogenic lipogenesis and overcomes metabolic compensation in oral squamous cell carcinoma
Abstract Metabolic reprogramming, particularly enhanced lipid anabolism, is a hallmark of oral squamous cell carcinoma (OSCC), yet effective therapies targeting this process remain lacking. Here, we identify concurrent activation of acetyl-CoA synthetase 2 (ACSS2) and ATP-citrate lyase (ACLY) as a cooperative metabolic driver of OSCC progression.
Cell-cycle-driven epigenetic resetting maintains meristematic cell fate for shoot branching
Abstract Cell proliferation generally promotes differentiation, whereas proliferative quiescence maintains stem cell identity—a paradigm well-established in adult mammalian stem cells. Here we report that in Arabidopsis bud precursor cells, meristematic cell fate maintenance depends on active cell-cycle progression. We identify two opposing mechanisms that balance trimethylated histone H3 Lys27 levels to regulate transcription of the shoot meristem marker gene SHOOT MERISTEMLESS (STM).
Chronic stress drives tumorigenesis and progression via central nervous system-mediated neuroimmune circuits
Abstract Chronic exposure to severe social and environmental stressors is a major risk factor for tumor initiation and progression, yet the central nervous system (CNS)-driven mechanisms linking stress to cancer immunity remain poorly defined. Here, we identify activation of the hypothalamic-pituitary-bone marrow (HPB) axis as a critical driver of oral squamous cell carcinoma (OSCC).
Mesoporous-Shell Monolayer Plasmonic Architecture Enables Quantitative and Decision-Guided SERS (Adv. Sci. 60/2026)
How to cite Huang, G., Wang, Y., Fang, Y., Shao, J., Hao, S., Zhao, M., Yao, Y., Wang, J., Zhou, W. and Wang, H. (2026), Mesoporous-Shell Monolayer Plasmonic Architecture Enables Quantitative and Decision-Guided SERS (Adv. Sci. 60/2026). Adv. Sci., 13: e78258. https://doi.org/10.1002/advs.78258 How to cite text copied to clipboard! COPY TEXT Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.
Serine protease inhibitor A3 is a soluble SIRPα ligand that suppresses inflammation and antitumor immunity
Abstract SIRPα is an inhibitory receptor with the canonical ligand CD47. Here, we show that human serine protease inhibitor A3 (SERPINA3) and its mouse ortholog SERPINA3k function as soluble binders and activators of SIRPα, suppressing SIRPα+ macrophages, neutrophils, dendritic cells and natural killer cells. SERPINA3(k) treatment alleviates lipopolysaccharide-induced pneumonia and ameliorates experimental autoimmune encephalomyelitis and rheumatoid arthritis.
Alopecia areata coexisting with Hashimoto’s thyroiditis and Sjögren’s syndrome: case report of hair regrowth and selected laboratory changes during combination treatment including tofacitinib
Abstract Background: Alopecia areata (AA) is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hashimoto’s thyroiditis (HT) and Sjögren’s syndrome (SS) are common systemic autoimmune disorders that may share genetic and immunological predispositions with AA. Co-occurrence of all three conditions is rarely reported.
Identification of model-ranked candidate medical interventions for pediatric atopic dermatitis using Dempster-Shafer evidence theory
Abstract Atopic dermatitis (AD) is common in infants and children, but comparative evidence for ranking drug combinations at the individual-patient level remains limited. Pathological and diagnostic data from 1,736 pediatric patients with AD were collected. After major measured confounding factors were screened, 455 patients with relatively low EASI scores were retained.
Modulating time refraction via collisional plasma-formed photonic time interfaces
Abstract Temporal interfaces created by abrupt refractive-index changes enable frequency conversion and underpin photonic time crystals, but bidirectional control in a single physical system remains difficult. Here we show that collisional plasma provides pressure-controlled bidirectional microwave frequency modulation.
Regulatory T cell dysfunction and therapeutic advances in rheumatoid arthritis, psoriasis, vitiligo, and systemic lupus erythematosus
Abstract Regulatory T cells (Tregs) are a critical immunosuppressive subset of CD4+ T cells, whose lineage stability and suppressive function rely on the transcription factor FOXP3. Within inflamed tissue microenvironments, Tregs maintain immune homeostasis and preserve tissue integrity via multiple mechanisms, including secretion of anti-inflammatory cytokines such as IL-10 and TGF-β, CD39/CD73-mediated adenosine metabolic pathways, and CTLA-4-dependent cell-contact inhibition.
Hydrolysis of 1,4-Butanediol-Derived Polyesters Into Tetrahydrofuran and Dicarboxylic Acids Over Lewis Acidic Ionic Liquids
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supporting information of this article.
Accuracy of a respiratory assessment chatbot in a nationwide messaging system for layperson diagnosis and triage: a randomized preregistered study
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Abstract Artificial intelligence (AI) tools are increasingly used for health information seeking, but their performance in layperson respiratory diagnosis and triage remains uncertain in prospective comparative studies. We assessed LungDiag, a task-constrained WeChat-based GPT-4o chatbot with a respiratory knowledge layer, against conventional mobile web search in a prospective, non-interventional, multicentre, single-blind, randomized simulated-case comparison.
By Jinghao Liang, Ying Wang, Yiwen Cai Verified, Jiaqi Wang, Yuhan Shi, Tao Guo, Jiawei Huang, Zishan Huang, Zhihua Guo, Jiping Li, Bin Liu, Ruowei Sun, Run Wang, Ziming Wei, Haiyuan Wu, Gaoyang Ye, Jing Zhou, Sheng Feng, Hengrui Liang, Weiqiang Yin, Jianxing He, Jingchun Ni, Kongmin Chen, Beiqun Chen, Chaoqi Dong, Zongrui Pu, Shaowei Qi, Shuifang Huang, Tianhao Guan
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Nature
Verified
Associations between vaccine misinformation and influenza vaccine uptake: a population-based interrupted time-series study in China
Abstract Vaccine misinformation is linked to vaccine hesitancy, yet real-world evidence of its association with vaccine uptake remains limited. Most existing studies rely on self-reported intentions or experimental designs, offering little insight into population-level behavioural changes. Using influenza vaccination data from Zhejiang, China, we examined changes in vaccination trends coinciding with three misinformation events.
Charting sex and age specific brain morphology in major depressive disorder
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Abstract Major depressive disorder (MDD) is associated with brain structural abnormalities, yet how these abnormalities vary across age and sex remain incompletely understood. Here, we aimed to characterize sex-stratified age-related brain morphological patterns in patients with MDD across a broad age range.
By Kangjia Chen, Xuemei Li, Yang Huang, Qingjin Liu, Wenxia Li, Jinpeng Niu, Jiang Qiu, Yong Zhang, Shaoqiang Han, Kai Wang, Dong Zhang, Bo Zhou, Gong-Jun Ji, Ying Wang, Yuan Chen, Guanqun Yao, Yong Xu, Tao Zhang, Xi Zhang, Liyuan Li, Xuan OuYang, Ruiyang Wang, Huafu Chen, Xinyu Zhou, Jiao Li, Wei Liao
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Nature
Verified
How culture promotes the social integration of migrants
Abstract Rural-to-urban migration in China has intensified, highlighting the critical challenge of social integration, as migrants’ marginalization often leads to adverse socioeconomic outcomes. This study investigates how development and entertainment-type cultural consumption influence migrant social integration.
From off-site viewing to the intention to create: multimodal heritage cues in social media heritage food posts
ABSTRACT Social media makes heritage food visible before destination visits, yet visibility alone does not explain why off-site viewers become willing to create content. This study develops multimodal heritage-cue configuration, defined as the coordinated use of textual and visual cues communicating origin, craft, place, sensory qualities, social embeddedness, and memory.
Multiplicity of Solutions for Nonlocal Elliptic Equations With Singular and Critical Hardy–Sobolev Nonlinearity
Conflicts of Interest The author declares no conflicts of interest. Data Availability Statement No new data was created or analyzed in this study. Data sharing is not applicable. References 1, , and , “Non-Local Gradient Dependent Operators,” Advanced Mathematics 230 (2012): 1859–1894. 2, , and , “Nonlocal Tug-Of-War and the Infinity Fractional Laplacian,” Communications on Pure and Applied Mathematics 65 (2012): 337–380.
EaMIC3 inhibits cell apoptosis and facilitates Eimeria acervulina infection through interacting with EpCAM
Abstract Coccidiosis, caused by Eimeria acervulina, is a pathogenic protozoan disease, leading to huge economic losses to the global poultry industry. At the early stage of E. acervulina infection, microneme protein 3 (EaMIC3) is involved in the inhibition of infected host cell apoptosis, but the underlying mechanisms remain unclear. Here, EaMIC3 was shown to inhibit the apoptosis of infected host cells and facilitate parasite infection by interacting with epithelial cell adhesion molecule (EpCAM).
Author Correction: Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8 + T cell fate
Correction to: Nature Immunology https://doi.org/10.1038/s41590-026-02578-4, published online 6 July 2026. In the version of the article initially published, in the “Under RNA-seq and data analyses” section of the Methods, the last sentence of the “Data generation” paragraph was “The RNA-seq FASTQ files of CD8+ TN cells were previously reported and deposited at the GEO (GSE164712)” but should have been “The RNA-seq data of CD8+ TN cells were newly generated and deposited at the GEO (GSE343749)”.
BBOX1 Deficiency Exacerbates Liver Fibrosis Through Carnitine Biosynthesis Disruption Rescued by Carnitine Supplementation
Handling Editor: Luca Valenti Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The raw sequence data of RNA were deposited in the NCBI SRA database with the accession number of PRJNA1217840. The authors confirm that the data supporting the findings of this study are available within the article. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request (Yu Gao, gaoyu@bbmu.edu.cn).
Optimal siting and sizing of pumped-storage power plants in a multi-HVDC-infeed regional power grid via AC security feedback
Abstract In regional power grids with multiple high-voltage direct-current (HVDC) infeeds, renewable-generation variability, variations in HVDC power transfers, and network constraints are strongly coupled, while planning solutions derived from DC power-flow models may not ensure AC operational feasibility. To address these issues, we propose an AC-security-feedback-based method for the siting and sizing of pumped-storage power plants.
Covalent organic frameworks with ultra-broadband absorption for efficient solar-driven water evaporation
Abstract Covalent organic frameworks (COFs) demonstrate application prospects in solar-driven water evaporation (SDWE). Nevertheless, the reported COFs intrinsically lack the capacity to harvest infrared light, which results in inferior photothermal conversion efficiency and thereby retards the water evaporation rate. Here we report a class of Cl-functionalized COFs with ultra-broadband absorption spanning 200–1,500 nm and strong non-radiative relaxation capacity for enhancing SDWE performance.
All of Us diversity and scale yield context-dependent improvements in polygenic prediction
Abstract Polygenic risk scores (PRSs) trained on multiancestry data can improve prediction in under-represented groups, but large linked genetic and health datasets capturing broad human diversity remain limited. Using 245,388 whole-genome sequences from the All of Us research program (AoU) together with UK Biobank data, we developed multiancestry PRSs for 32 traits and diseases.
Hantavirus: biology, immune responses, and pathogenesis
Abstract The recent Andes virus (ANDV) outbreak on the MV Hondius cruise has raised global public health alarms due to its dangerous ability to person-to-person spread. Hantavirus infections primarily manifest as hemorrhagic fever with Eurasian renal syndrome (HFRS) and Americas hantavirus cardiopulmonary syndrome (HCPS), both characterized by endothelial manifestation.
Harnessing machine learning and multi-source data fusion for regional geohazard risk assessment of a rapidly urbanizing mountainous region
Abstract Rapid urbanization in mountainous regions often intensifies the conflict between engineering activities and the geological environment. in southeastern Sichuan Province, the study area is experiencing heightened geological disaster risks driven by its accelerated urbanization. To quantify this conflict, we developed an integrated hazard–vulnerability–risk assessment workflow.
Flavonoid C -glycosides: from structure-activity relationships to food applications
Abstract Flavonoid C-glycosides are a class of plant‑derived natural products in which the sugar moiety is directly linked to the flavonoid aglycone via a C-C bond. Although the nutritional and health benefits of flavonoid C-glycosides are receiving increasing attention and popularity, the relationship between their structure and bioactivity remains unknown, which seriously hinders the development and utilization of these compounds in functional foods.
Localized potential wells enabling directional electron transport boost photocatalytic uranium extraction from natural seawater
Abstract The directional induction of photoelectron transport to atomic active sites is critical for boosting photocatalytic uranium extraction; however, achieving such tuning remains a grand challenge. Here we report a localized potential well engineering strategy that facilitates the directional injection of photogenerated electrons towards the atomic active sites, which enhance photocatalytic uranium extraction from natural seawater.
Information reliability and engagement patterns of Alzheimer’s disease-related short videos on Douyin and Bilibili
Abstract Health-related content is increasingly disseminated through short-video platforms. However, the relationship between user engagement and informational reliability remains uncertain. This issue is particularly important for Alzheimer’s disease (AD), where patients and caregivers rely heavily on accessible information. We screened the first 100 search results from each platform and included eligible Alzheimer’s disease-related videos from Douyin and Bilibili.
The LrAN2-LrSOS3 regulatory module enhances salt tolerance and anthocyanin accumulation in Lycium ruthenicum
Abstract Abiotic stress-induced anthocyanin accumulation enhances stress tolerance and improves the quality of fruits, vegetables, and other horticultural crops. The promising natural blue colorant petanin, mainly derived from the wild resource of Lycium ruthenicum fruit, has attracted considerable attention for food industrial applications. Metabolic engineering of petanin in L. ruthenicum callus (LRC) provides a promising strategy to increase petanin yield in our previous study.
A hypoxia/necrosis-driven metabolic-epigenetic axis H3K9 lactylation-mediated SKP2 signaling promotes glioblastoma progression
Abstract Tumor hypoxia/necrosis as a hallmark of glioblastoma (GBM) is strongly associated with malignant progression and poor prognosis of GBM, however, its roles and mechanisms in the behaviors of neighboring surviving GBM cells remain poorly understood. Here, we analyzed public transcriptomic datasets to characterize gene expression in hypoxic/necrotic regions in GBM, and found that the glycolytic pathway was activated in tumor cells from these regions.
HMGCS2-mediated ketogenesis maintains intestinal barrier in inflammatory bowel disease by inhibiting ferroptosis
Abstract Complete mucosal healing is a key therapeutic goal in inflammatory bowel disease (IBD). While ferroptosis-mediated epithelial cell death is known to compromise the mucosal barrier as the cornerstone of mucosal healing, the precise mechanisms driving this process during IBD pathogenesis remain to be fully elucidated.
Single-Cell Immune Profiling Suggests Non-Classical Monocyte Is Associated Immunodepression in Tuberculosis Treatment Non-Responders
1 Background The prevalence of Tuberculosis (TB) and its unfavourable treatment outcome posed a threat to the World Health Organization (WHO) End TB Strategy targets by 2035 [1]. Unfavourable treatment outcomes are influenced by multiple factors, including bacteriological characteristics, demographics, clinical history, health care delivery and socioeconomic conditions [2, 3].
Triglyceride-glucose index is associated with the severity of coronary artery disease
Loading metrics Open Access Peer-reviewed Research Article Citation: Wang D, Wang Y, Li F, Wang Z, Zeng K, Yan S, et al. (2026) Triglyceride-glucose index is associated with the severity of coronary artery disease. PLoS One 21(8): e0356426. https://doi.org/10.1371/journal.pone.0356426 Editor: Paolo Magni, Università degli Studi di Milano, ITALY Received: December 4, 2024; Accepted: August 3, 2026; Published: August 17, 2026 Copyright: © 2026 Wang et al.
Excess copper compromises hippocampal function in major depressive disorder: a study on clinical and animal evidence
Abstract Dysregulation of copper (Cu) metabolism may contribute to the pathogenesis of major depressive disorder (MDD) by disrupting hippocampal function. The aim of this study is to elucidate the neurobiological mechanisms through integrated clinical and animal experiments. A total of 85 MDD patients and 65 healthy controls (HCs) were recruited for this study. Serum Cu, ceruloplasmin (Cp) levels, and the relative mRNA expression of ATPase copper-transporting alpha (Atp7a) were measured.
A frog bioactive peptide suppresses inflammation by modulating autophagy for skin wound regeneration
Abstract Failure of inflammation resolution is a key driver of chronic skin wound pathogenesis, highlighting importance in wound healing. Although autophagy is known to regulate this process, it remains unclear whether amphibian-derived peptides exert their effects to facilitate regeneration of wounds through autophagy. Here, we identified OL-RA11, a previously unreported autophagy-regulatory peptide from Odorrana livida, which exhibits potent therapeutic effects on skin wounds.
Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy
Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and antioxidant systems, the complete transcriptional network through which AR regulates ferroptosis remains incompletely defined.
Blood metabolomic signatures linking air pollution to lung cancer in the Cancer Prevention Studies
Abstract Air pollution is a leading environmental cause of lung cancer, yet the underlying biological pathways remain poorly understood. Identifying circulating biomarkers that capture early molecular responses may clarify how air pollutants contribute to carcinogenesis and help identify individuals at elevated risk.
Author Correction: Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance
Correction to: Nature https://doi.org/10.1038/s41586-023-05767-5 Published online 8 March 2023 In the version of this article initially published, in Fig. 2c and associated Source Data, there were duplication errors in the NIP7 URB1-KD and DDX31 scramble profiles, and in the primer sequences in Supplementary Table 1, the POLR1D-F and POLR1D-R entries were duplicates of the POLR1C-F data. The figure, Source Data and supplementary table have been updated in the HTML and PDF versions of this article.
The effect of intrauterine platelet-rich plasma infusion on pregnancy outcomes in patients with recurrent implantation failure
Abstract Does intrauterine platelet-rich plasma (PRP) infusion improve frozen embryo transfer (FET) outcomes in patients with recurrent implantation failure (RIF)? which patient subgroups benefit most significantly? This retrospective study (July 2023-March 2025) analyzed 1,846 frozen embryo transfer (FET) cycles from patients under 40 with ≥ 3 previous implantation failures. Pregnancy outcomes were compared between the PRP group (571 cycles) and the control group (1,275 cycles).
Dynamic prediction of preterm birth and gestational age at delivery based on longitudinal electronic health records
Abstract This study introduces GestaCare, a deep learning framework designed to jointly optimize all-cause preterm birth (PTB) risk classification and time-to-delivery regression.
Adjunctive traditional Chinese medicine for ischemic stroke: a systematic review with structured narrative synthesis and GRADE assessment of randomized controlled trials
Abstract Ischemic stroke is a leading cause of death and long-term disability, and traditional Chinese medicine (TCM) is widely used alongside conventional care in East Asia. We reviewed randomized controlled trials (RCTs) of adjunctive TCM in ischemic stroke, analyzing the evidence by clinical phase and by individual formulation rather than as a single treatment class.
Spatial distribution characteristics and protection strategies of National intangible cultural heritage in the Pearl river basin
Abstract While the spatial analysis of Intangible Cultural Heritage (ICH) is well-established at national and provincial scales, cross-jurisdictional river basins remain a critical research gap. This study investigates the spatial heterogeneity of 289 national-level ICH items within China’s Pearl River Basin to inform regional conservation planning.
A Multicenter Integrative Cohort Characterizing the Genetic, Clinical, and Transcriptomic Features of ACP5 Deficiency
A Multicenter Integrative Cohort Characterizing the Genetic, Clinical, and Transcriptomic Features of ACP5 Deficiency - Zhong - Arthritis & Rheumatology - Wiley Online Library
Integrated air-coupled ultrasonic transducer with front-end preamplification for structural health monitoring
Abstract Air-coupled ultrasonic testing provides non-contact structural evaluation for scenarios in which liquid or gel couplants are impractical. However, its field deployment is limited by severe acoustic impedance mismatch, microvolt-scale received signals, electromagnetic interference, and cable-induced signal degradation.
Effects of walking training with blood flow restriction on the hemodynamics and perceptual responses among sedentary college students: A randomized crossover trial
Loading metrics Open Access Peer-reviewed Research Article Citation: Zhu Y, Wang Y, Yu S, Sun D, Ji X, Yuan W, et al. (2026) Effects of walking training with blood flow restriction on the hemodynamics and perceptual responses among sedentary college students: A randomized crossover trial. PLoS One 21(7): e0352582.
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