Ying-Ying Liu
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CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO-TA-Induced Cardiac Senescence via Mitophagy Defect and cGAS-STING Activation: In Vitro Amelioration by Cycloastragenol (Adv. Sci. 56/2026)
How to cite Li, N.-W., Jiang, J.-Z., Liu, Y.-Y., Zhang, T.-T., Malhi, K.K., Yao, X. and Li, J.-L. (2026), CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO-TA-Induced Cardiac Senescence via Mitophagy Defect and cGAS-STING Activation: In Vitro Amelioration by Cycloastragenol (Adv. Sci. 56/2026). Adv. Sci., 13: e77800.
Targeting iRhom2-mediated PANoptosis ameliorates acute kidney injury
Abstract Although PANoptosis plays a pivotal role in the pathogenesis of acute kidney injury (AKI), the underlying regulatory mechanisms and effective therapeutic strategies remain largely unexplored. In this study, we report a novel function of inactive rhomboid 2 (iRhom2), encoded by the Rhbdf2 gene, in promoting PANoptosis in tubular epithelial cells (TECs).
CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO-TA-Induced Cardiac Senescence via Mitophagy Defect and cGAS-STING Activation: In Vitro Amelioration by Cycloastragenol
1 Introduction Per- and polyfluoroalkyl substances (PFAS) comprise a large family of synthetic organofluorine compounds characterized by exceptional hydrophobicity and oleophobicity. These properties have led to their extensive application in diverse industrial and consumer products, including food contact materials, textile treatments, pharmaceutical manufacturing, firefighting foams, and aerospace and construction components [1, 2].
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