Ying-Ying Liu

1 Introduction Per- and polyfluoroalkyl substances (PFAS) comprise a large family of synthetic organofluorine compounds characterized by exceptional hydrophobicity and oleophobicity. These properties have led to their extensive application in diverse industrial and consumer products, including food contact materials, textile treatments, pharmaceutical manufacturing, firefighting foams, and aerospace and construction components [1, 2].

1 Introduction Monoterpenoids are a large and diverse group of naturally occurring compounds whose basic structure consists of two isoprene units [1, 2], playing an irreplaceable role in pharmaceuticals or agrochemicals due to their diverse bioactivities [3-5]. Besides, owing to their characteristic odor and taste, many monoterpenoids or their derivatives have also been applied in cosmetic materials [6], food flavors [7], or insect repellents [8, 9].

Abstract Recent studies show that telomerase reverse transcriptase (TERT) possesses important new biological functions in gene transcription regulation, signal transduction, tumorigenesis, vascular development and mitochondrial DNA protection independent of the maintenance of telomere length. In this study we investigated the role and mechanisms of TERT in regulating the gene expression and signal transduction during pressure overload-induced cardiac remodeling.