Ying-Yu Lin
As seen in:
Nature,
BioRxiv,
Cell Stem Cell,
The Diplomat Magazine,
RealClear Defense,
RealClear World
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Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling
Abstract Retinal microvascular diseases involve a compromised inner blood–retina barrier (iBRB), which remains poorly understood. A renewable source of human iBRB endothelium is thus vital for advancing eye research and treatment development. Here we differentiated human induced pluripotent stem cells into retinal endothelial cells (iRECs) via the Wnt–β-catenin pathway, namely Norrin–Frizzled4 signalling. These iRECs show genetic, protein and functional fidelity as well as unique retinal features.
Control the oil, shape the world: Trump’s disruptive diplomacy and the risks for Taiwan
More than a year into his presidency, US President Donald Trump has played a disruptor role, leaving his mark on every aspect of diplomacy, from military strategy to economic tariffs. A lot of this has to do with Trump’s personality and style. What impact does this have on the Taiwan Strait issues? Academic Ying-yu Lin gives an analysis. US President Donald Trump during a news conference at the White House in Washington, DC, US, on 6 April 2026.
Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modeling
Abstract Retinal microvascular diseases involve a compromised inner blood-retina barrier (iBRB), which remains poorly understood. A renewable source of human iBRB endothelium is thus vital for advancing eye research and treatment development. Here, we differentiated human iPSCs into retinal endothelial cells (iRECs) via the Wnt/β-catenin pathway, namely Norrin/Frizzled4 signaling. These iRECs show genetic, protein, and functional fidelity and unique retinal features.
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