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Yingai Zhang on Muck Rack

Yingai Zhang

As seen in: Nature
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Articles

Polystyrene nanoplastics and benzo(a)pyrene synergistically induce lung fibrosis and inflammation via relaxin signalling in mice

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By Yu Chen, Yingai Zhang, Yuting Zhang, Xu Zhang, Mohamed Ali Mohsen, Xiaoshan Zhu, Kai Yin, Hailong Zhou, Shuguo lv
| Nature Verified
Abstract Micro- and nanoplastics (MNPs) are emerging pollutants that can carry harmful substances like benzo(a)pyrene, posing potential health risks. While the harmful effects of nanoplastics on the lungs are known, how they interact with benzo(a)pyrene to affect cellular communication remains unclear. In our study, We explore this interplay using a 16-week mouse model exposed to environmentally relevant doses of polystyrene nanoplastics, benzo(a)pyrene, or a combination of both.
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PRICE: direct and robust detection of microRNAs at single-nucleotide resolution - Nature Communications

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By Buhua Wang, Shuai Zhou, Xi Zhang, Rui Wang, Shuo Huang, Anyi Li, Haowei He, Yangdao Wei, Zhiqing Yang, Fengge Song, Xiangpeng Li, Xinyi Wan, Yi Shen, Chunxin Ma, Rodrigo Ledesma-Amaro, Dapeng Yin, Qingshan Wei, Ruijie deng, Tao Yang, Shanrong Liu, Yi Wan, Chuanbin Mao, Yingai Zhang, Haimei Mao
| Nature Verified
Abstract Accurate single-nucleotide discrimination of miRNA is clinically vital because small sequence variations can have significant phenotypic and clinical consequences, yet existing techniques can only detect single nucleotide variations (SNVs) at specific loci. Here, we present a generalized peptide nucleic acid (PNA) mediated CRISPR/Cas13a system (PRICE), enabling detection of SNVs in miRNA sequence without sacrificing the sensitivity.
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