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Yingbo Li on Muck Rack

Yingbo Li

As seen in: Nature, Wiley, Wiley Online Library, Frontiers, MDPI, Technovation, ACS Publications, Canadian Journal of Infectious Diseases & Medical Microbiology, Dove Medical Press, Optica
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Articles

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor-Draining Lymph Nodes of Breast Cancer

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By Yingbo Li, Di Chang, Jie Yang
| Wiley Online Library Verified
1 Introduction Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is notorious for its rapid progression, early systemic spread, and lack of effective targeted therapies [1-4]. Its poor prognosis stems from a profoundly immunosuppressive tumor microenvironment (TME) that blunts the efficacy of chemotherapy, targeted therapy, and emerging immunotherapies [5, 6].
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Programmable nanomicelles rewire myeloid immunity for durable control of primary and metastatic breast cancer

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By Jie Yang, Di Chang, Yingbo Li, Zuoyu Xu, Daoshuang Li, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Jianqiong Zhang, Jinbing Xie, Zebin Xiao, Shenghong Ju
| Nature Verified
Abstract Immunosuppressive myeloid cells, including immature dendritic cells (DC) and tumor-promoting macrophages, drive tumor progression and immune evasion. Reprogramming these cells into immune effectors remains challenging. Here, we present a programmable nanomicelle platform that reconfigures myeloid immunity to combat both primary and metastatic breast cancer (BC). The nanomicelles co-deliver photosensitizers (IR825), anti-PD-L1 antibodies, and antagomiR-182 with spatiotemporal precision.
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Spatiotemporally Controlled Nanomicelles for Synergistic Phototherapy and Immune Reprogramming in Triple-Negative Breast Cancer

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By Di Chang, Jie Yang, Yingbo Li, Shudan Min
| dx.doi.org
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See all 16 licensed articles (17 Total)