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Advances and prospects of large DNA fragment editing in plants - Nature Plants
Abstract Structural variations drive plant genome evolution and shape agronomic traits. Manipulating structural variations has great potential to improve complex plant traits and enhance agricultural sustainability. Genome editing technologies have evolved from gene knockouts and base editing to the modification of short DNA fragments, and are now advancing towards the precise manipulation of large DNA fragments.
OsHLP1 is an endoplasmic-reticulum-phagy receptor in rice plants
Highlights • OsHLP1 maintains endoplasmic reticulum (ER) homeostasis by ER-phagy in rice plants • OsHLP1 associates with OsATG8b via LIR motifs and IDR domain to activate ER-phagy • The immune regulator OsNTL6 is the cargo protein of OsHLP1-mediated ER-phagy • OsHLP1-OsATG8b-OsNTL6 module contributes to immune activation in rice plants Summary The endoplasmic reticulum (ER) is the largest intracellular endomembrane system; it shows dynamic changes upon environmental stress.
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