Yingchao Gong

Abstract Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remodeling in terminally differentiated cardiomyocytes.

Abstract Cardiac hypertrophy is a pivotal risk factor for heart failure. Hypertension-induced pressure overload triggers left ventricular hypertrophy and leads to heart failure. Although the precise mechanisms remain incompletely elucidated, recent studies highlighted the role of ubiquitin-proteasome system in this process. As a heart tissue-enriched E3 ligase, the function of Asb10 in cardiac hypertrophy remains unknown.

Introduction Epidemiological data indicate that cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are the most common cause of death in the United States.1, 2 Studies have shown that in those over 64 years old, more than 60% of type 2 diabetic (T2D) patients die from cardiovascular diseases, imposing a heavy burden on families and healthcare systems.3 Although there are many factors that contribute to the risk of...