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Articles

MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy

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By Yanni Lin, Meiyin Zhang, Zhiyuan Tang, Wenxing Qin, Min Xiao, Xue Sun, Yuli Shen, Zhiqiang Hu, Shuo Ru, Yuran Duan, Bofei Dong, Ting Wen, Mengdie Li, Hong Wu, Yueru Hou, Guimei Ji, Zheng Wang, Xiaohong Wu, Qimin Zhou, Xiaoguang Liu, Gaopeng Li, Yuhao Wang, Shengzhong Duan, Yang Luo, Bo Chu, Xu Qian, Zhimin Lu, Yuan Ding, Chuan Xu, tong liu, Daqian Xu, Peixiang Zheng
| Nature Verified
Abstract Limited efficacy of neoadjuvant chemotherapy (NAC) in pancreatic ductal adenocarcinoma (PDAC) underscores the need for novel combination strategies and a deeper understanding of metabolic determinants of chemoresistance. Here we identify methylmalonate semialdehyde dehydrogenase (MMSDH), a valine catabolism enzyme, as a driver of gemcitabine (GC) resistance. Hypoxia induces GCN5-mediated lactylation of MMSDH at K113.
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An operational perturbation proteomics-based virtual cell model

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By Rui Sun, Liujia Qian, Yongge Li, tong liu, Honghan Cheng, Xuedong Zhang, Xueya Zhou, Yuecheng Zhan, Guangmei Zhang, Kunpeng Ma, Chunlong Wu, Dongchen Ji, Zhangzhi Xue, Hongxue Meng, Yuhang Xiang, Qianhe Zhou, Wenbin Hu, Yuhan Deng, Lingling Tan, Qi Xiao, Zhiwei Liu, Lei Zeng, Liqin Qian, Xuan Zheng, Qiong Hu, Peijie Zhou, Yi Zhu, Tiannan Guo, Zhengchao Luo, Dingwei Lei, Nianzi Luo
| Nature Verified
Abstract Artificial intelligence-empowered virtual cell models represent an emerging approach for in silico drug discovery1,2,3, yet most existing approaches lack large-scale, time-resolved perturbation proteomics data and interpretable frameworks for predicting therapeutic responses. Here we generated more than 38 million temporal protein-abundance measurements from systematically perturbed breast cancer cell lines, and developed ProteinTalks, a virtual cell model.
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The Impact of Patient Capital

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By Yingxiang (Catherine) Li, tong liu, Ting Xu
| National Bureau of Economic Research
We thank Fabrizio Core, Victoria Ivashina, Bo Li, Xiyue Li, Kevin Tseng as well as conference and seminar participants at the AIEA-NBER Conference on Innovation and Entrepreneurship, NBER SI Entrepreneurship, LTI-Bank of Italy Workshop on Long-term Investors' Trends, CICF, WEFI conference, University of Connecticut, University of Toronto, Tsinghua PBC, SAIF, ShanghaiTech University, and Bentley University for helpful comments.
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