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Cover Feature: Engineering Nicotinamide Adenine Dinucleotide Oxidase for Regeneration of Oxidized Non‐natural Cofactor (ChemBioChem 16/2025)
Graphical Abstract Oxidative and reductive reactions are vital processes in cellular metabolism. Like yin and yang in Tai Chi, they are independent and complementary. The non-natural cofactors NCD+ and NCDH exhibit substantial potential for the bio-orthogonal regulation of redox pathways. To provide sufficient driving force, it is crucial to maintain the NCD+ and NCDH ratio and homeostasis. In the Research Article 10.1002/cbic.202500254, Xueying Wang, Zongbao K.
Engineering Nicotinamide Adenine Dinucleotide Oxidase for Regeneration of Oxidized Non‐natural Cofactor
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description cbic202500254-sup-0001-SuppData-S1.pdf634.3 KB Supplementary Material References 1, , , Curr. Opin. Biotechnol. 2023, 84, 103019. 2, , , Curr. Opin. Biotechnol. 2020, 66, 217. 3, , , CIESC J. 2024, 75, 4037. 4, , , , , , , J. Am. Chem. Soc. 2011, 133, 20857. 5, , , , , , , , Tetrahedron Lett. 2025, 155, 155432. 6, , , , , , , , , , Nat. Chem. Biol. 2020, 16, 87. 7, , , , , , , J. Am. Chem. Soc. 2016, 138, 1033.
Effects of NAD+ Supplementation with Oral Nicotinamide Riboside (NR) on Vascular Health and Cognitive Function in Older Adults with Peripheral Artery Disease: Results from a Pilot 4-Week Open-Label Clinical Trial
Peripheral artery disease (PAD) is a major age-related vascular condition that significantly contributes to cardiovascular morbidity and mortality in older adults(Hirsch et al., 2001; Criqui et al., 2021).
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