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Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov
1 Introduction The registration of clinical trials is a fundamental requirement of medical research ethics, representing both an obligation and a moral responsibility for investigators. This practice facilitates the traceability of clinical trial outcomes and enhances the public availability and transparency of trial information (1). ClinicalTrials.gov is an online platform and database that provides detailed information on clinical research studies and their outcomes.
Quantitative analysis of the efficacy characteristics and influencing factors of weight loss drugs in children and adolescents
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description dom16599-sup-0001-supinfo.docxWord 2007 document , 1.2 MB Data S1. Supporting Information. REFERENCES 1 Obesity WHO https://www.who.int/health-topics/obesity#tab=tab_1. 2023 2, , , , , . Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents. Am J Clin Nutr. 2002; 75(6): 978-985.
Supramolecular nanoprodrug based on chloride channel blocker and glycosylated pillar[5]arene for targeted chemoresistance cancer therapy
Supramolecular nanoprodrug based on chloride channel blocker and glycosylated pillar[5]arene for targeted chemoresistance cancer therapy Ke Yang, Ke Ma, Manman Yang, Yinghua Lv, Yuxin Pei and Zhichao Pei Abstract A supramolecular nanoprodrug (DOX@GP5⊃Pro-NFA) was constructed based on the host–guest complexation of chloride channel blocker prodrug (Pro-NFA) and glycosylated pillar[5]arene (GP5), which could target tumor cells via galactose, esterase responsive release of drug to overcome drug...
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