Yinghui Feng
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Real-time visualization of collagen assembly uncovers metastable properties in hierarchical organization
Abstract Collagen, a central component of the extracellular matrix (ECM), precisely regulates tissue mechanical properties and biological functions through hierarchical assembly, playing a vital role in maintaining homeostasis. However, the molecular mechanism of assembly remains poorly understood, limiting insights into tissue remodeling, aging, and ECM-related diseases.
Fatigue Resistant Hydrogels Engineered With Twisting Hierarchical Structures
1 Introduction Hydrogels have emerged as a transformative class of soft materials with demonstrated versatility across wearable electronics [1], soft robotics [2], tissue engineering [3, 4], and implantable medical devices [5-7], leveraging their unique combination of high-water content (<80%), tissue-like compliance (Young's modulus of hundreds kPa), intrinsic softness and biocompatibility [8, 9].
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