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Yinghui Wei on Muck Rack

Yinghui Wei

As seen in: Nature, Wiley Online Library, Emergency Medicine Journal, MDPI, Taylor & Francis Online, Royal Society of Chemistry, Canadian Journal of Infectious Diseases & Medical Microbiology, Respiratory Medicine
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Articles

Noncanonical target-strand cytosine base editing via engineered Un1Cas12f1 platform - Nature Communications

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By Yinghui Wei, Yulin Chen, Xingxu Huang, Jianghuai Liu
| Nature Verified
Abstract CRISPR/Cas-derived base editors harness various deaminase or glycosylase activities to target bases within non-target strand (NTS) of the R-loop, catalyzing base conversions independent of double-strand break formation. To develop miniature BEs compatible with therapeutic viral vectors, we explore the compact Cas12f system. Through computational modeling and mutagenesis, we establish a highly active enUn1Cas12f1 protein, and subsequently construct the derivative cytosine BE (CBE).
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Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals - Nature Chemical Biology

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By Yinghui Wei, Guoling Li, Kun Xu, Zhaowei Wu
| Nature Verified
Abstract Eukaryotic transposon-encoded Fanzor proteins hold great promise for genome-engineering applications as a result of their compact size and mechanistic resemblance to TnpB. However, the unmodified Fanzor systems show extremely low activity in mammalian cells.
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Robust inference for the unification of confidence intervals in meta-analysis

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By Wei Liang, Hongsheng Dai, Yinghui Wei, Haicheng Huang
| Taylor & Francis Online
Meta-analysis is a statistical method to combine results from multiple studies, facilitating the inference-making process concerning specific parameters of interests, such as odds ratio. Parameters estimated from individual studies can be combined using either a fixed-effect or a random-effects meta-analysis model (Higgins and Thompson Citation2009; Deeks et al. Citation2022).
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