Yinghui Wu

Abstract Telomeric DNA replication involves coordinated action of telomerase and DNA polymerase α-primase (Polα/primase), which synthesize the G-strand and C-strand, respectively. The conserved Cdc13-Stn1-Ten1 (CST) complex critically regulates this process by both terminating telomerase activity and stimulating Polα/primase. While telomerase-mediated G-overhang synthesis is well studied, how CST-Polα/primase is recruited to telomeres for C-strand fill-in remains poorly understood.

Abstract Digital twins are comprised of computational models that mimic the ‘as built’ characteristics of devices, systems, and networks of systems whose performance in the real world warrants quantitative and critical assessment.The literature on constructing digital twins is historically focused around task-specific, physics-based models that seek to understand the device from first principles, thereby constructing an idealized digital twin, based on the known physics, of the...