Yinghui Xu
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Engineered immunosuppressive dendritic cells protect against cardiac remodelling
Abstract Heart failure remains a leading cause of morbidity and mortality, yet no approved therapies effectively prevent or reverse pathological cardiac fibrosis and the associated decline in cardiac function1,2,3,4. Chronic inflammation is a central driver of pathological fibrosis after ischaemic or haemodynamic stress, but strategies that locally rebalance injurious and reparative immune responses without systemic immunosuppression are lacking5,6.
A robust computational framework for methylation age and disease-risk prediction based on pairwise learning
7 hours ago If you’re ready to work from home—full-time and permanently—you need these indispensable resources. It’s that time again. The calendar has flipped, the resolutions are written, and you’re probably sitting in your office chair at your office desk looking at a lukewarm cup of office coffee, wondering …
FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine
1 Introduction Angiogenesis plays a crucial role in various physiological and pathological processes, including wound healing and tissue repair.[1-4] Endothelial cells (EC) can respond to ischemic stimuli to initiate angiogenesis.[5-8] Activated ECs undergoing a sprouting phenotype are called tip cells, which are central to new capillary bud formation to promote reparative angiogenesis.[1, 9, 10] Hence, understanding the mechanisms underlying angiogenesis holds promise for developing...
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