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Yingjia Chen

As seen in: Nature, Annals of the Rheumatic Diseases, The Journal of Immunology, Alzheimer's & Dementia
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Articles

Large-scale whole-genome sequencing reveals the landscape and health implications of de novo mutations

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By Na Qin, Juncheng Dai, Yue Jiang, Yuan Xie, Hong Lv, Jun L Zhou, Xiao Wang, Yangqian Jiang, Jiangbo Du, Yingjia Chen, Xianfeng Xu, Lingmin Hu, Congcong Chen, Ziye Xu, Jiawen Zhu, Yuhan Liu, Yu Wang, Ci Song, Yayun Gu, Tao Jiang, Bo Xu, Xiumei Han, Yuan Lin, Qingxia Meng, Xiufeng Ling, Hongxia Ma, Guangfu Jin, Cheng Wang, Hongbing Shen, Zhibin Hu
| Nature Verified
Abstract De novo mutations (DNMs) are an important source of congenital diseases. With delayed parenthood and assisted reproductive technology (ART) use increasing, it is essential to elucidate how these reproductive factors influence DNMs and whether resulting mutations influence offspring health. Here we performed whole-genome sequencing of 24,030 individuals from 7,851 parent−offspring families, identifying 390,924 de novo single-nucleotide variants (dnSNVs).
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Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-α in rheumatoid arthritis

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By Fanlei Hu, Lianjie Shi, Xiaohang Liu, Yingjia Chen
| Annals of the Rheumatic Diseases Verified
Objectives B10 and B10pro cells suppress immune responses via secreting interleukin (IL)-10. However, their regulators and underlying mechanisms, especially in human autoimmune diseases, are elusive. This study aimed to address these questions in rheumatoid arthritis (RA), one of the most common highly disabling autoimmune diseases. Methods The frequencies and functions of B10 and B10pro cells in healthy individuals and patients with RA were first analysed.
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Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses

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By Yingjia Chen, Diagnostic Imaging, Tamas Nagy
| Royal Society of Chemistry Verified
Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses† Yingjia Chen,a Kevin M. Guo,b Tamas Nagyc and Tai L.
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