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Articles

Large-scale whole-genome sequencing reveals the landscape and health implications of de novo mutations

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By Na Qin, Juncheng Dai, Yue Jiang, Yuan Xie, Hong Lv, Jun L Zhou, Xiao Wang, Yangqian Jiang, Jiangbo Du, Yingjia Chen, Xianfeng Xu, Lingmin Hu, Congcong Chen, Ziye Xu, Jiawen Zhu, Yuhan Liu, Yu Wang, Ci Song, Yayun Gu, Tao Jiang, Bo Xu, Xiumei Han, Yuan Lin, Qingxia Meng, Xiufeng Ling, Hongxia Ma, Guangfu Jin, Cheng Wang, Hongbing Shen, Zhibin Hu
| Nature Verified
Abstract De novo mutations (DNMs) are an important source of congenital diseases. With delayed parenthood and assisted reproductive technology (ART) use increasing, it is essential to elucidate how these reproductive factors influence DNMs and whether resulting mutations influence offspring health. Here we performed whole-genome sequencing of 24,030 individuals from 7,851 parent−offspring families, identifying 390,924 de novo single-nucleotide variants (dnSNVs).
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ROS-induced ATP synthase mRNA degradation and metabolism dysfunction reveals the mechanism of artificial deteriorated cotton seeds

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By Ci Song, Junming Zhang, Zhenzhen Xing
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Citation: Song C, Zhang J, Xing Z, Gu F, Chen J (2026) ROS-induced ATP synthase mRNA degradation and metabolism dysfunction reveals the mechanism of artificial deteriorated cotton seeds. PLoS One 21(2): e0339977. https://doi.org/10.1371/journal.pone.0339977 Editor: Smita Kumar, King George's Medical University, INDIA Received: September 9, 2025; Accepted: December 15, 2025; Published: February 10, 2026 Copyright: © 2026 Song et al.
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Dynamics of Particle Migration Toward Interface and Tailored Directional Migration Strategy in Multiphase Melt Processing

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By Li-Bo Chen, Ci Song, Zheng Lu, Zhe-Xue Tao
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “Research Progress and Application of Multimodal Flexible Sensors for Electronic Skin,” ACS Sensors 9 (2024): 2275–2293, https://doi.org/10.1021/acssensors.4c00307. 2, , , , , and , “Stimuli-Responsive fiber/Fabric Actuators for Intelligent Soft Robots: From Current Progress to Future Opportunities,” Nano Energy 129 (2024): 110050, https://doi.org/10.1016/j.nanoen.2024.110050.
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