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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD
Section snippets Hepatic fibrosis: a challenge in the treatment of MASLD Chronic liver diseases due to viral hepatitis, biliary obstruction, hepatotoxins, and metabolic disorders may lead to hepatic fibrosis, characterized by an excessive wound-healing response and aberrant deposition of extracellular matrix (ECM; see Glossary) proteins [1].
Butyrate Modification Promotes Intestinal Absorption and Hepatic Cancer Cells Targeting of Ferroptosis Inducer Loaded Nanoparticle for Enhanced Hepatocellular Carcinoma Therapy
Abstract Sorafenib is an oral-administered first-line drug for hepatocellular carcinoma (HCC) treatment. However, the therapeutic efficacy of sorafenib is relatively low. Here, an oral delivery platform that increases sorafenib uptake by HCC and induces potent ferroptosis is designed. This platform is butyrate-modified nanoparticles separately encapsulated with sorafenib and salinomycin.
Complying the Physiological Functions of Golgi Apparatus for Secretory Exocytosis Facilitated Oral Absorption of Protein Drugs
Complying the Physiological Functions of Golgi Apparatus for Secretory Exocytosis Facilitated Oral Absorption of Protein Drugs Intestinal epithelial cells are the primary biological barriers for oral administrated nano-formulations and the delivered protein drugs.
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