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Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Vesicular stomatitis virus (VSV) and rabies and Chandipura viruses belong to the Rhabdovirus family. VSV is a common laboratory virus to study viral evolution and host immune responses to viral infection, and recombinant VSV-based vectors have been widely used for viral oncolysis, vaccination, and gene therapy. Although the tropism of VSV is broad, and its envelope glycoprotein G is often used for pseudotyping other viruses, the host cellular components involved in VSV infection remain unclear.
Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Author contributions: BD, MYL and MQ conceived and coordinated the study. BD, NZ and HJH designed, performed and analyzed the experiments and wrote the paper. NZ and HJH designed, performed and analyzed the experiments shown in Figures 1, 6 and 7. NZ, BHT, YLW and QQX designed, performed and analyzed the experiments shown in Figure 2, 3. HJH, YY and NNW designed, performed and analyzed the experiments shown in Figure 4, 5. LLH designed and constructed vectors for expression of proteins.
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