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Yingli Wu on Muck Rack

Yingli Wu

As seen in: Nature, MDPI, ACS Publications, Dove Medical Press
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Articles

TRMT1-mediated tRNA m 2 2 G modification drives Osimertinib resistance via the ATXN3/USP25 axis in lung adenocarcinoma

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By Jiaqi Li, Bo Jing, Yingying Wang, Wenhui Bai, Qiuyu Wei, Meng Liu, Kuofang Huang, Shifei Pan, Haijiao Lu, Jialin Qian, Yanjie Ji, Wanting Liu, Hua Zhong, Youping Zhang, Wenxuan Wu, Luo Hao, Hu Lei, Hanzhang Xu, Yingli Wu, Tianqing Chu, Chujiao Zhu, Xuxinyi Ling, Huishu Dong, Yuanhui Zhai
| Nature Verified
Abstract Acquired resistance to Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), remains a critical challenge in lung adenocarcinoma. Here, we identify ATXN3, a deubiquitinating enzyme, as a driver of Osimertinib resistance and a predictor of poor patient survival. Osimertinib treatment dynamically upregulates ATXN3 transcription, which stabilizes USP25 through deubiquitination, activating an ATXN3-USP25-TRMT1 signaling cascade.
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Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer - Signal Transduction and Targeted Therapy

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By Xinlei Cai, Liang Hu, Yingli Wu, Hongbin Ji
| Nature Verified
Abstract Oncogenic KRAS mutations are frequently detected in NSCLC. It remains a major challenge to target all KRAS mutants. MEK inhibitors are considered candidates for treating KRAS-mutant NSCLC; however, their easy adaptive resistance precludes further application.
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Lipotoxicity: A New Perspective in Type 2 Diabetes Mellitus

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By Biaohua Chen, Tiangang Li, Yingli Wu, Liyun Song
| Dove Medical Press
Back to Journals » Diabetes, Metabolic Syndrome and Obesity » Volume 18 Review Diabetes Pathophysiology and Complications Authors Chen B , Li T, Wu Y , Song L , Wang Y, Bian Y, Qiu Y, Yang Z Received 19 December 2024 Accepted for publication 14 April 2025 Published 24 April 2025 Volume 2025:18 Pages 1223—1237 DOI https://doi.org/10.2147/DMSO.S511436 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Rebecca Conway...
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