Yingui Cao
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A dual-site oral nanovaccine programs anti-colorectal tumor immunity from small intestinal priming to large intestinal boosting
Abstract Oral vaccines hold great promise for colorectal cancer (CRC) immunotherapy but are limited by inefficient mucosal delivery and a lack of spatiotemporal control over immune activation. Here we report a spatiotemporally programmed oral nanovaccine that implements a dual-site vaccination strategy through a sequential and causally linked immune cascade, initiating immune priming in Peyer’s patches of the small intestine and subsequently amplifying immunity at colorectal tumor sites.
Oral Plant‐Derived Nanomedicines Mitigate Acetaminophen‐Induced Liver Injury by Modulating the Gut‐Liver Axis and Intestinal Microbiota Metabolism
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202502001-sup-0001-SuppMat.docx28.9 MB Supporting Information References 1, Hepatology 2004, 40, 10. 2, , , , , , , , , , , Hepatology 2005, 42, 1364. 3, , Adv. Pharmacol. 2019, 85, 263. 4, , , , Toxicol. Sci. 2020, 174, 159. 5, , , , Redox Biol. 2018, 17, 274. 6, , , Gut 2020, 69, 1867. 7, , , J. Hepatol. 2020, 72, 558. 8, , , , , , , , , , , , Cell Rep. 2024, 43, 113591.
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