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Yingxian Shi

As seen in: Royal Society of Chemistry
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Articles

HD-ALP Fluorescent Probe: A High-Sensitivity Tool for Alkaline Phosphatase Imaging and Preclinical Diagnosis in Three Ovarian Cancer Models

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By Yingxian Shi, Ruirui Dong, Huan Huang, Gaoying Wang
| Royal Society of Chemistry Verified
HD-ALP Fluorescent Probe: A High-Sensitivity Tool for Alkaline Phosphatase Imaging and Preclinical Diagnosis in Three Ovarian Cancer Models Ovarian cancer (OC) remains a prevalent gynecological malignancy, posing significant threats to women's health globally. Emerging evidence underscores the critical involvement of alkaline phosphatase (ALP) in OC pathogenesis, prompting the development of targeted diagnostic tools.
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BR2 cell penetrating peptide effectively delivers anti-p21Ras scFv to tumor cells with ganglioside expression for therapy of ras-driven tumor

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By Ting Yu, Xinyan Pan, Qiang Feng, Yingxian Shi
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Abstract Purpose Cell membrane penetrating peptide BR2 can bind with ganglioside and introduce foreign drugs into tumor cells. In this study, we employed BR2 to carry the broad-spectrum anti-p21Ras scFv prepared in our laboratory into ganglioside expressing tumor cells for therapy of ras-driven tumors. Methods BR2-p21Ras scFv gene was cloned to prokaryotic expression vector and expressed in E.
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