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Implementing acute exacerbations of COPD care bundles: evidence, effectiveness and future directions
Introduction Chronic obstructive pulmonary disease (COPD) remains a major global health challenge. The World Health Organization estimated that COPD caused 3.5 million deaths in 2021, accounting for approximately 5% of all global deaths, with nearly 90% of premature COPD deaths occurring in low- and middle-income countries [1].
Multicentre double-blind randomised controlled trial of systematic corticosteroid therapy in patients with acute exacerbations of chronic obstructive pulmonary disease admitted to hospital with higher eosinophil levels: the ECHO protocol
Methods Study design This is an investigator-initiated, multicentre, randomised, double-blind, parallel controlled, superiority trial in the respiratory departments or the respiratory and critical care medicine departments at 12 general hospitals in Beijing. The details of the participating hospitals are listed in online supplemental appendix 1. The study was prospectively registered with ClinicalTrials.gov on 10 August 2021.
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