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Yingxin Celia Jiang

As seen in: Nature
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Articles

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity - Nature

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By Naiqi Wang, Zhian Chen, Yin Yao, Chenglong Sun, Wei Wei, Lei Sun, Hao Zhang, Feng LI, Daniel Butcher, Shi-Ran Sun, Jialei Gong, Yanfei Qi, Jingxuan Huang, Rui Liu, Xiaoyue Zheng, Chenyu Li, Haoyuan Geng, Limin Zhao, Hongjian Sun, Yexin Ge, Mehrdad Pazhouhandeh, Christopher K Barlow, Katherine Jeppe, Joseph Yunis, Chen Zhu, Yunbo Wei, Xiaowen Liang, Kim Bridle, David Frazer, Siok-Keen Tey, Yuhua Li, Zhaohui Yang, Minglei Shu, Zheng Liu, Darrell Crawford, Di Yu, Yingxin Celia Jiang, Sam Nettelfield
| Nature Verified
Abstract Ferroptosis, a major mechanism of non-apoptotic programmed cell death, critically regulates the homeostasis and functionality of peripheral CD4+ and CD8+ T cells1,2,3,4,5,6. Here we demonstrate that in mouse, resistance of T cells to ferroptosis depends critically on the composition of standard rodent diets, and that dietary effects on ferroptosis (DEFs) have a crucial role in regulation of T cell homeostasis and immune responses.
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