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Christopher K Barlow on Muck Rack

Christopher K Barlow

As seen in: Nature, Wiley Online Library, PLOS Biology, BioRxiv, Cell Press, JD Supra, Hitched (UK), Creativepool
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Articles

Lipidomic profiling reveals a distinct lipidomic signature of early gestational diabetes

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By Saeede Saadati, Rasoul Godini, Christopher K Barlow, Christopher Nolan, David Simmons, Helena J. Teede, Aya Mousa, Eveline Jona, Adriana CH Neven
| Nature Verified
Abstract Gestational diabetes mellitus (GDM) diagnosed early in pregnancy (before 20 weeks’ gestation) is associated with increased metabolic risk, yet its molecular profile remains poorly defined. While disrupted lipid metabolism is an important feature of GDM, no previous study has characterized the lipidomic profile of women with early GDM (eGDM).
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Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP

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By Gamze Kuser-Abali, Fumihito Noguchi, Peinan Zhao, Pacman Szeto, Youfang Zhang, Cheng Huang, Christopher K Barlow, Giovanna Pomilio, Marion Boudes, Christopher Chew, Samar Masoumi Moghaddam, Isobel Leece, Jen Cheung, Malaka Ameratunga, Nicholas Wong, Miles C Andrews, Ralf B. Schittenhelm, Andrew Wei, Vivek Naranbhai, Chen Davidovich, Mark Shackleton
| Cell Press Verified
ArticleVolume 86, Issue 13p2521-2538.e10Open access Affiliations & Notes 1Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia 2Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia 3Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia 4Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia 5Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash...
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Lipid metabolism drives dietary effects on T cell ferroptosis and immunity - Nature

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By Naiqi Wang, Zhian Chen, Yin Yao, Chenglong Sun, Wei Wei, Lei Sun, Hao Zhang, Feng LI, Daniel Butcher, Shi-Ran Sun, Jialei Gong, Yanfei Qi, Jingxuan Huang, Rui Liu, Xiaoyue Zheng, Chenyu Li, Haoyuan Geng, Limin Zhao, Hongjian Sun, Yexin Ge, Mehrdad Pazhouhandeh, Christopher K Barlow, Katherine Jeppe, Joseph Yunis, Chen Zhu, Yunbo Wei, Xiaowen Liang, Kim Bridle, David Frazer, Siok-Keen Tey, Yuhua Li, Zhaohui Yang, Minglei Shu, Zheng Liu, Darrell Crawford, Di Yu, Yingxin Celia Jiang, Sam Nettelfield
| Nature Verified
Abstract Ferroptosis, a major mechanism of non-apoptotic programmed cell death, critically regulates the homeostasis and functionality of peripheral CD4+ and CD8+ T cells1,2,3,4,5,6. Here we demonstrate that in mouse, resistance of T cells to ferroptosis depends critically on the composition of standard rodent diets, and that dietary effects on ferroptosis (DEFs) have a crucial role in regulation of T cell homeostasis and immune responses.
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