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Yingxin He

As seen in: Nature, Wiley Online Library, MDPI, medRxiv
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Articles

Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue

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By Soumya Mukherjee, Eleanor Moncur, Alicja Szadziewska, Yingxin He, Przemysław R. Kac, Reid A. Coyle, Elena Camporesi, Chihiro Sato, Nupur Ghoshal, Nicolas Barthelemy, Nicolas R. Barthélemy, Jack Wood, Junyue Ge, Maciej Dulewicz, Srinivas Koutarapu, Katherine E Schwetye, Kaleigh Roberts, Eimear Murphy, Kaj Blennow, Fernando Ortiz, Claire Leckey, Tatiana A Giovannucci, Kanza Tariq, Henrik Zetterberg, Donald L. Elbert, Lewis Thorne, Ahmed K. Toma, Laurence D. Watkins, Nick Fox Verified, Randall J. Bateman, Jörg Hanrieder, Ross W. Paterson, Aram Aslanyan, Francesco Carletti
| Nature Verified
Abstract Alzheimer disease begins in the brain many years before symptoms, but early changes are usually studied after death or indirectly through fluid and imaging biomarkers. Here we show that small brain biopsies collected during ventriculoperitoneal shunt surgery can be used to study Alzheimer disease pathology and protein turnover during life.
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Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

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By John B Coulton, Yingxin He, Melissa M Budelier, Nicolas Barthelemy, Nicolas R. Barthélemy
| Wiley Online Library Verified
Neurofilaments (NFs) are key cytoskeletal proteins that regulate axon integrity.1 NFs are primarily expressed in neurons and are represented by three subunits: neurofilament light (NfL), neurofilament medium (NfM), and neurofilament heavy (NfH) that complex with α-internexin in the central nervous system (CNS) or peripherin in the peripheral nervous system (PNS).
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Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial - Communications Medicine

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By Mitzi M. Gonzales, Valentina R. Garbarino, Marisa Lopez-Cruzan, Veronica Galvan, Miranda Orr, Yingxin He, Randall J. Bateman
| Nature Verified
Abstract Rapamycin has been shown to extend lifespan and acts on pathologies underlying Alzheimer’s disease and related dementias in animal models. However, rapamycin’s clinical application remains underexplored. We conducted a single-site open-label phase 1 clinical trial (ClinicalTrials.gov: NCT04200911) to examine the effects of rapamycin in humans.
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