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Yingxin He on Muck Rack

Yingxin He

As seen in: Nature, Wiley Online Library, MDPI, medRxiv
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Articles

Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

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By John B Coulton, Yingxin He, Melissa M Budelier, Nicolas Barthelemy, Nicolas R. Barthélemy
| Wiley Online Library Verified
Neurofilaments (NFs) are key cytoskeletal proteins that regulate axon integrity.1 NFs are primarily expressed in neurons and are represented by three subunits: neurofilament light (NfL), neurofilament medium (NfM), and neurofilament heavy (NfH) that complex with α-internexin in the central nervous system (CNS) or peripherin in the peripheral nervous system (PNS).
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Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial - Communications Medicine

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By Mitzi M. Gonzales, Valentina R. Garbarino, Marisa Lopez-Cruzan, Veronica Galvan, Miranda Orr, Yingxin He, Randall J. Bateman
| Nature Verified
Abstract Rapamycin has been shown to extend lifespan and acts on pathologies underlying Alzheimer’s disease and related dementias in animal models. However, rapamycin’s clinical application remains underexplored. We conducted a single-site open-label phase 1 clinical trial (ClinicalTrials.gov: NCT04200911) to examine the effects of rapamycin in humans.
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Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease - Nature Medicine

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By Kanta Horie, Gemma Salvadó, Shorena Janelidze, Yingxin He, Chihiro Sato, Brian Gordon, David M. Holtzman, Sebastian Palmqvist, Suzanne Schindler, Oskar Hansson
| Nature Verified
Abstract Insoluble tau aggregates within neurofibrillary tangles are a defining neuropathological feature of Alzheimer’s disease (AD) and closely correlate with clinical symptoms. Although tau pathology can be assessed using tau positron emission tomography, a more accessible biomarker is needed for diagnosis, prognosis and tracking treatment effects.
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